1. #4 Ohio State at #5 Indiana Time: 12:00 PM ET Spread: Ohio State -3.5 Over/Under: 51.5 Matchup: A top-five Big Ten showdown with major College Football Playoff implications. Indiana has home-field advantage in what could be the game of the week. 2. #2 Notre Dame at #8 BYU Time: 7:30 PM ET Spread: Notre Dame -10.5 Over/Under: 46.5 Matchup: Notre Dame travels to Provo for a major ranked matchup against BYU. The lower total points toward a potentially more defensive game. 3.