Must Watch Week 4 College Football Games

Week 4 brings ESPN College GameDay to Knoxville, TN and one of the most loaded Saturdays of the 2026 college football season, with ranked teams colliding across the SEC and Big Ten. Here are the biggest matchups and the betting numbers heading into the weekend.

1 Texas at 14 Tennessee — Texas -4.5, O/U 55.5

The No. 1 Longhorns head into Knoxville for a massive SEC showdown with No. 14 Tennessee. Texas is a 5.5-point road favorite, making this one of the weekend's most intriguing games from both a football and betting perspective.

23 Texas A&M at 10 LSU — LSU -8.5, O/U 56.5

No. 23 Texas A&M travels to Baton Rouge to take on No. 10 LSU in another SEC battle between ranked teams. LSU enters as a 6.5-point favorite at home, while the total sits in the mid-50s. With both teams looking to make a statement in conference play, this could be one of Saturday's most entertaining games.

4 Ole Miss at 21 Florida — Florida -3.5, O/U 59

No. 4 Ole Miss travels to face No. 21 Florida. Florida enters 3-0, while Ole Miss comes off a statement win over LSU. The Gators are a short home favorite, and the nearly 60-point total suggests a game with plenty of offensive potential.

20 Oregon at 12 USC — Oregon -3, O/U 63

The No. 20 Ducks visit No. 12 USC in a Big Ten matchup with the highest total among the marquee games. At 63 points, oddsmakers are expecting fireworks in Los Angeles.

17 Iowa at 18 Michigan — Michigan -5.5, O/U 38.5

No. 17 Iowa and No. 18 Michigan offer a completely different betting profile. The 38.5-point total is easily the lowest among the major ranked matchups, pointing toward a more defensive, field-position-oriented game.

Bottom line: From Texas-Tennessee at noon to Oregon-USC under the lights, Saturday delivers a full day of ranked matchups, conference rivalries and betting numbers worth watching.

Betting lines subject to change - ESPN